DIRAS2 is Associated with Adult ADHD, Related Traits, and Co-Morbid Disorders
Identifieur interne : 000B02 ( Main/Exploration ); précédent : 000B01; suivant : 000B03DIRAS2 is Associated with Adult ADHD, Related Traits, and Co-Morbid Disorders
Auteurs : Andreas Reif [Allemagne] ; T. Trang Nguyen [Allemagne] ; Lena Weissflog [Allemagne] ; Christian P. Jacob [Allemagne] ; Marcel Romanos [Allemagne] ; Tobias J. Renner [Allemagne] ; Henriette N. Buttenschon [Danemark] ; Sarah Kittel-Schneider [Allemagne] ; Alexandra Gessner [Allemagne] ; Heike Weber [Allemagne] ; Maria Neuner [Allemagne] ; Silke Gross-Lesch [Allemagne] ; Karin Zamzow [Allemagne] ; Susanne Kreiker [Allemagne] ; Susanne Walitza [Suisse] ; Jobst Meyer [Allemagne] ; Christine M. Freitag [Allemagne] ; Rosa Bosch [Espagne] ; Miquel Casas [Espagne] ; Nuria Gomez [Espagne] ; Marta Ribases [Espagne] ; M Nica Bayes [Espagne] ; Jan K. Buitelaar [Pays-Bas] ; Lambertus Alm Kiemeney [Pays-Bas] ; J. J. Sandra Kooij [Pays-Bas] ; Cees C. Kan [Pays-Bas] ; Martine Hoogman [Pays-Bas] ; Stefan Johansson [Norvège] ; Kaya K. Jacobsen [Norvège] ; Per M. Knappskog [Norvège] ; Ole B. Fasmer ; Phil Asherson ; Andreas Warnke [Allemagne] ; Hans-Jörgen Grabe ; Jessie Mahler ; Alexander Teumer ; Henry Völzke ; Ole N. Mors [Danemark] ; Helmut Sch Fer [Allemagne] ; Josep Antoni Ramos-Quiroga [Espagne] ; Bru Cormand ; Jan Haavik [Norvège] ; Barbara Franke [Pays-Bas] ; Klaus-Peter Lesch [Allemagne]Source :
- Neuropsychopharmacology : (New York, NY) [ 0893-133X ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
Abstract
Several linkage analyses implicated the chromosome 9q22 region in attention deficit/hyperactivity disorder (ADHD), a neurodevelopmental disease with remarkable persistence into adulthood. This locus contains the brain-expressed GTP-binding RAS-like 2 gene (DIRAS2) thought to regulate neurogenesis. As DIRAS2 is a positional and functional ADHD candidate gene, we conducted an association study in 600 patients suffering from adult ADHD (aADHD) and 420 controls. Replication samples consisted of 1035 aADHD patients and I38I controls, as well as I66 families with a child affected from childhood ADHD. Given the high degree of co-morbidity with ADHD, we also investigated patients suffering from bipolar disorder (BD) (n = 336) or personality disorders (PDs) (n = 622). Twelve single-nucleotide polymorphisms (SNPs) covering the structural gene and the transcriptional control region of DIRAS2 were analyzed. Four SNPs and two haplotype blocks showed evidence of association with ADHD, with nominal p-values ranging from p = 0.006 to p = 0.05. In the adult replication samples, we obtained a consistent effect of rs I4I2005 and of a risk haplotype containing the promoter region (p = 0.026). Meta-analysis resulted in a significant common OR of I.I2 (p = 0.04) for rsI4I2005 and confrmed association with the promoter risk haplotype (OR= 1.45, p=0.0003). Subsequent analysis in nuclear families with childhood ADHD again showed an association of the promoter haplotype block (p = 0.02). rs I4I2005 also increased risk toward BD (p = 0.026) and cluster B PD (p = 0.03i). Additional SNPs showed association with personality scores (p = 0.008-0.048). Converging lines of evidence implicate genetic variance in the promoter region of DIRAS2 in the etiology of ADHD and co-morbid impulsive disorders.
Affiliations:
- Allemagne, Danemark, Espagne, Norvège, Pays-Bas, Suisse
- Bavière, District de Basse-Franconie, District de Darmstadt, District de Giessen, Gueldre, Hesse (Land), Rhénanie-Palatinat
- Francfort-sur-le-Main, Marbourg, Nimègue, Trèves (Allemagne), Wurtzbourg
- Université de Trèves
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000373
- to stream PascalFrancis, to step Corpus: 000469
- to stream PascalFrancis, to step Curation: 000978
- to stream PascalFrancis, to step Checkpoint: 000316
- to stream Main, to step Merge: 000B49
- to stream Main, to step Curation: 000B02
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">DIRAS2 is Associated with Adult ADHD, Related Traits, and Co-Morbid Disorders</title><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Trang Nguyen, T" sort="Trang Nguyen, T" uniqKey="Trang Nguyen T" first="T." last="Trang Nguyen">T. Trang Nguyen</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Biometry and Epidemiology, University of Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Weissflog, Lena" sort="Weissflog, Lena" uniqKey="Weissflog L" first="Lena" last="Weissflog">Lena Weissflog</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>University of Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Jacob, Christian P" sort="Jacob, Christian P" uniqKey="Jacob C" first="Christian P." last="Jacob">Christian P. Jacob</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>University of Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Romanos, Marcel" sort="Romanos, Marcel" uniqKey="Romanos M" first="Marcel" last="Romanos">Marcel Romanos</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Renner, Tobias J" sort="Renner, Tobias J" uniqKey="Renner T" first="Tobias J." last="Renner">Tobias J. Renner</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Buttenschon, Henriette N" sort="Buttenschon, Henriette N" uniqKey="Buttenschon H" first="Henriette N." last="Buttenschon">Henriette N. Buttenschon</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre for Psychiatric Research, Aarhus University Hospital</s1><s2>Risskov</s2><s3>DNK</s3><sZ>7 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Risskov</wicri:noRegion></affiliation></author><author><name sortKey="Kittel Schneider, Sarah" sort="Kittel Schneider, Sarah" uniqKey="Kittel Schneider S" first="Sarah" last="Kittel-Schneider">Sarah Kittel-Schneider</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Gessner, Alexandra" sort="Gessner, Alexandra" uniqKey="Gessner A" first="Alexandra" last="Gessner">Alexandra Gessner</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Weber, Heike" sort="Weber, Heike" uniqKey="Weber H" first="Heike" last="Weber">Heike Weber</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Neuner, Maria" sort="Neuner, Maria" uniqKey="Neuner M" first="Maria" last="Neuner">Maria Neuner</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Gross Lesch, Silke" sort="Gross Lesch, Silke" uniqKey="Gross Lesch S" first="Silke" last="Gross-Lesch">Silke Gross-Lesch</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>University of Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Zamzow, Karin" sort="Zamzow, Karin" uniqKey="Zamzow K" first="Karin" last="Zamzow">Karin Zamzow</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Biometry and Epidemiology, University of Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Kreiker, Susanne" sort="Kreiker, Susanne" uniqKey="Kreiker S" first="Susanne" last="Kreiker">Susanne Kreiker</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>University of Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Walitza, Susanne" sort="Walitza, Susanne" uniqKey="Walitza S" first="Susanne" last="Walitza">Susanne Walitza</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Child and Adolescent Psychiatry, University of Zuerich</s1><s2>Zuench</s2><s3>CHE</s3><sZ>15 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Zuench</wicri:noRegion></affiliation></author><author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Neurobehavioral Genetics, University of Trier, Institute of Psychobiology</s1><s2>Trier</s2><s3>DEU</s3><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Institute of Psychobiology</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Freitag, Christine M" sort="Freitag, Christine M" uniqKey="Freitag C" first="Christine M." last="Freitag">Christine M. Freitag</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Child and Adolescent Psychiatry, Goethe University Frankfurt am Main</s1><s2>Frankfurt</s2><s3>DEU</s3><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Bosch, Rosa" sort="Bosch, Rosa" uniqKey="Bosch R" first="Rosa" last="Bosch">Rosa Bosch</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Psychiatry, Hospital Universitari Vall d'Hebron</s1><s2>Barcelona, Catalonia</s2><s3>ESP</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Barcelona, Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Casas, Miquel" sort="Casas, Miquel" uniqKey="Casas M" first="Miquel" last="Casas">Miquel Casas</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Psychiatry, Hospital Universitari Vall d'Hebron</s1><s2>Barcelona, Catalonia</s2><s3>ESP</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Barcelona, Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Gomez, Nuria" sort="Gomez, Nuria" uniqKey="Gomez N" first="Nuria" last="Gomez">Nuria Gomez</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Psychiatry, Hospital Universitari Vall d'Hebron</s1><s2>Barcelona, Catalonia</s2><s3>ESP</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Barcelona, Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Ribases, Marta" sort="Ribases, Marta" uniqKey="Ribases M" first="Marta" last="Ribases">Marta Ribases</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Psychiatry, Hospital Universitari Vall d'Hebron</s1><s2>Barcelona, Catalonia</s2><s3>ESP</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Barcelona, Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Bayes, M Nica" sort="Bayes, M Nica" uniqKey="Bayes M" first="M Nica" last="Bayes">M Nica Bayes</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Centro Nacional de Análisis Genómico (CNAG)</s1><s2>Barcelona, Catalonia</s2><s3>ESP</s3><sZ>22 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Centro Nacional de Análisis Genómico (CNAG)</wicri:noRegion></affiliation></author><author><name sortKey="Buitelaar, Jan K" sort="Buitelaar, Jan K" uniqKey="Buitelaar J" first="Jan K." last="Buitelaar">Jan K. Buitelaar</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>23 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Kiemeney, Lambertus Alm" sort="Kiemeney, Lambertus Alm" uniqKey="Kiemeney L" first="Lambertus Alm" last="Kiemeney">Lambertus Alm Kiemeney</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>24 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Kooij, J J Sandra" sort="Kooij, J J Sandra" uniqKey="Kooij J" first="J. J. Sandra" last="Kooij">J. J. Sandra Kooij</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>PsyQ Psycho-Medical Programs, Program Adult ADHD</s1><s2>The Hague</s2><s3>NLD</s3><sZ>25 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>The Hague</wicri:noRegion></affiliation></author><author><name sortKey="Kan, Cees C" sort="Kan, Cees C" uniqKey="Kan C" first="Cees C." last="Kan">Cees C. Kan</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Hoogman, Martine" sort="Hoogman, Martine" uniqKey="Hoogman M" first="Martine" last="Hoogman">Martine Hoogman</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Johansson, Stefan" sort="Johansson, Stefan" uniqKey="Johansson S" first="Stefan" last="Johansson">Stefan Johansson</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Medical Genetics and Molecular Medicine, Haukeland University Hospital</s1><s2>Bergen</s2><s3>NOR</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Biomedicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Jacobsen, Kaya K" sort="Jacobsen, Kaya K" uniqKey="Jacobsen K" first="Kaya K." last="Jacobsen">Kaya K. Jacobsen</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Medical Genetics and Molecular Medicine, Haukeland University Hospital</s1><s2>Bergen</s2><s3>NOR</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Biomedicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Knappskog, Per M" sort="Knappskog, Per M" uniqKey="Knappskog P" first="Per M." last="Knappskog">Per M. Knappskog</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Medical Genetics and Molecular Medicine, Haukeland University Hospital</s1><s2>Bergen</s2><s3>NOR</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Fasmer, Ole B" sort="Fasmer, Ole B" uniqKey="Fasmer O" first="Ole B." last="Fasmer">Ole B. Fasmer</name></author><author><name sortKey="Asherson, Phil" sort="Asherson, Phil" uniqKey="Asherson P" first="Phil" last="Asherson">Phil Asherson</name></author><author><name sortKey="Warnke, Andreas" sort="Warnke, Andreas" uniqKey="Warnke A" first="Andreas" last="Warnke">Andreas Warnke</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Grabe, Hans Jorgen" sort="Grabe, Hans Jorgen" uniqKey="Grabe H" first="Hans-Jörgen" last="Grabe">Hans-Jörgen Grabe</name></author><author><name sortKey="Mahler, Jessie" sort="Mahler, Jessie" uniqKey="Mahler J" first="Jessie" last="Mahler">Jessie Mahler</name></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name></author><author><name sortKey="Mors, Ole N" sort="Mors, Ole N" uniqKey="Mors O" first="Ole N." last="Mors">Ole N. Mors</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre for Psychiatric Research, Aarhus University Hospital</s1><s2>Risskov</s2><s3>DNK</s3><sZ>7 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Risskov</wicri:noRegion></affiliation></author><author><name sortKey="Sch Fer, Helmut" sort="Sch Fer, Helmut" uniqKey="Sch Fer H" first="Helmut" last="Sch Fer">Helmut Sch Fer</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Biometry and Epidemiology, University of Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Ramos Quiroga, Josep Antoni" sort="Ramos Quiroga, Josep Antoni" uniqKey="Ramos Quiroga J" first="Josep Antoni" last="Ramos-Quiroga">Josep Antoni Ramos-Quiroga</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Psychiatry, Hospital Universitari Vall d'Hebron</s1><s2>Barcelona, Catalonia</s2><s3>ESP</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Barcelona, Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Cormand, Bru" sort="Cormand, Bru" uniqKey="Cormand B" first="Bru" last="Cormand">Bru Cormand</name></author><author><name sortKey="Haavik, Jan" sort="Haavik, Jan" uniqKey="Haavik J" first="Jan" last="Haavik">Jan Haavik</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Biomedicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Lesch, Klaus Peter" sort="Lesch, Klaus Peter" uniqKey="Lesch K" first="Klaus-Peter" last="Lesch">Klaus-Peter Lesch</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>University of Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0458339</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0458339 INIST</idno><idno type="RBID">Pascal:11-0458339</idno><idno type="wicri:Area/PascalFrancis/Corpus">000373</idno><idno type="stanalyst">FRANCIS 11-0458339 INIST</idno><idno type="wicri:Area/PascalFrancis/Corpus">000469</idno><idno type="wicri:Area/PascalFrancis/Curation">000978</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000316</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000316</idno><idno type="wicri:doubleKey">0893-133X:2011:Reif A:diras:is:associated</idno><idno type="wicri:Area/Main/Merge">000B49</idno><idno type="wicri:Area/Main/Curation">000B02</idno><idno type="wicri:Area/Main/Exploration">000B02</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">DIRAS2 is Associated with Adult ADHD, Related Traits, and Co-Morbid Disorders</title><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Trang Nguyen, T" sort="Trang Nguyen, T" uniqKey="Trang Nguyen T" first="T." last="Trang Nguyen">T. Trang Nguyen</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Biometry and Epidemiology, University of Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Weissflog, Lena" sort="Weissflog, Lena" uniqKey="Weissflog L" first="Lena" last="Weissflog">Lena Weissflog</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>University of Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Jacob, Christian P" sort="Jacob, Christian P" uniqKey="Jacob C" first="Christian P." last="Jacob">Christian P. Jacob</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>University of Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Romanos, Marcel" sort="Romanos, Marcel" uniqKey="Romanos M" first="Marcel" last="Romanos">Marcel Romanos</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Renner, Tobias J" sort="Renner, Tobias J" uniqKey="Renner T" first="Tobias J." last="Renner">Tobias J. Renner</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Buttenschon, Henriette N" sort="Buttenschon, Henriette N" uniqKey="Buttenschon H" first="Henriette N." last="Buttenschon">Henriette N. Buttenschon</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre for Psychiatric Research, Aarhus University Hospital</s1><s2>Risskov</s2><s3>DNK</s3><sZ>7 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Risskov</wicri:noRegion></affiliation></author><author><name sortKey="Kittel Schneider, Sarah" sort="Kittel Schneider, Sarah" uniqKey="Kittel Schneider S" first="Sarah" last="Kittel-Schneider">Sarah Kittel-Schneider</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Gessner, Alexandra" sort="Gessner, Alexandra" uniqKey="Gessner A" first="Alexandra" last="Gessner">Alexandra Gessner</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Weber, Heike" sort="Weber, Heike" uniqKey="Weber H" first="Heike" last="Weber">Heike Weber</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Neuner, Maria" sort="Neuner, Maria" uniqKey="Neuner M" first="Maria" last="Neuner">Maria Neuner</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Gross Lesch, Silke" sort="Gross Lesch, Silke" uniqKey="Gross Lesch S" first="Silke" last="Gross-Lesch">Silke Gross-Lesch</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>University of Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author><author><name sortKey="Zamzow, Karin" sort="Zamzow, Karin" uniqKey="Zamzow K" first="Karin" last="Zamzow">Karin Zamzow</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Biometry and Epidemiology, University of Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Kreiker, Susanne" sort="Kreiker, Susanne" uniqKey="Kreiker S" first="Susanne" last="Kreiker">Susanne Kreiker</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>University of Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Walitza, Susanne" sort="Walitza, Susanne" uniqKey="Walitza S" first="Susanne" last="Walitza">Susanne Walitza</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Child and Adolescent Psychiatry, University of Zuerich</s1><s2>Zuench</s2><s3>CHE</s3><sZ>15 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Zuench</wicri:noRegion></affiliation></author><author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Neurobehavioral Genetics, University of Trier, Institute of Psychobiology</s1><s2>Trier</s2><s3>DEU</s3><sZ>16 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Institute of Psychobiology</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Freitag, Christine M" sort="Freitag, Christine M" uniqKey="Freitag C" first="Christine M." last="Freitag">Christine M. Freitag</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Child and Adolescent Psychiatry, Goethe University Frankfurt am Main</s1><s2>Frankfurt</s2><s3>DEU</s3><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Bosch, Rosa" sort="Bosch, Rosa" uniqKey="Bosch R" first="Rosa" last="Bosch">Rosa Bosch</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Psychiatry, Hospital Universitari Vall d'Hebron</s1><s2>Barcelona, Catalonia</s2><s3>ESP</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Barcelona, Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Casas, Miquel" sort="Casas, Miquel" uniqKey="Casas M" first="Miquel" last="Casas">Miquel Casas</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Psychiatry, Hospital Universitari Vall d'Hebron</s1><s2>Barcelona, Catalonia</s2><s3>ESP</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Barcelona, Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Gomez, Nuria" sort="Gomez, Nuria" uniqKey="Gomez N" first="Nuria" last="Gomez">Nuria Gomez</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Psychiatry, Hospital Universitari Vall d'Hebron</s1><s2>Barcelona, Catalonia</s2><s3>ESP</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Barcelona, Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Ribases, Marta" sort="Ribases, Marta" uniqKey="Ribases M" first="Marta" last="Ribases">Marta Ribases</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Psychiatry, Hospital Universitari Vall d'Hebron</s1><s2>Barcelona, Catalonia</s2><s3>ESP</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Barcelona, Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Bayes, M Nica" sort="Bayes, M Nica" uniqKey="Bayes M" first="M Nica" last="Bayes">M Nica Bayes</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Centro Nacional de Análisis Genómico (CNAG)</s1><s2>Barcelona, Catalonia</s2><s3>ESP</s3><sZ>22 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Centro Nacional de Análisis Genómico (CNAG)</wicri:noRegion></affiliation></author><author><name sortKey="Buitelaar, Jan K" sort="Buitelaar, Jan K" uniqKey="Buitelaar J" first="Jan K." last="Buitelaar">Jan K. Buitelaar</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>23 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Kiemeney, Lambertus Alm" sort="Kiemeney, Lambertus Alm" uniqKey="Kiemeney L" first="Lambertus Alm" last="Kiemeney">Lambertus Alm Kiemeney</name><affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>24 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Kooij, J J Sandra" sort="Kooij, J J Sandra" uniqKey="Kooij J" first="J. J. Sandra" last="Kooij">J. J. Sandra Kooij</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>PsyQ Psycho-Medical Programs, Program Adult ADHD</s1><s2>The Hague</s2><s3>NLD</s3><sZ>25 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>The Hague</wicri:noRegion></affiliation></author><author><name sortKey="Kan, Cees C" sort="Kan, Cees C" uniqKey="Kan C" first="Cees C." last="Kan">Cees C. Kan</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Hoogman, Martine" sort="Hoogman, Martine" uniqKey="Hoogman M" first="Martine" last="Hoogman">Martine Hoogman</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Johansson, Stefan" sort="Johansson, Stefan" uniqKey="Johansson S" first="Stefan" last="Johansson">Stefan Johansson</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Medical Genetics and Molecular Medicine, Haukeland University Hospital</s1><s2>Bergen</s2><s3>NOR</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Biomedicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Jacobsen, Kaya K" sort="Jacobsen, Kaya K" uniqKey="Jacobsen K" first="Kaya K." last="Jacobsen">Kaya K. Jacobsen</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Medical Genetics and Molecular Medicine, Haukeland University Hospital</s1><s2>Bergen</s2><s3>NOR</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Biomedicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Knappskog, Per M" sort="Knappskog, Per M" uniqKey="Knappskog P" first="Per M." last="Knappskog">Per M. Knappskog</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Medical Genetics and Molecular Medicine, Haukeland University Hospital</s1><s2>Bergen</s2><s3>NOR</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Fasmer, Ole B" sort="Fasmer, Ole B" uniqKey="Fasmer O" first="Ole B." last="Fasmer">Ole B. Fasmer</name></author><author><name sortKey="Asherson, Phil" sort="Asherson, Phil" uniqKey="Asherson P" first="Phil" last="Asherson">Phil Asherson</name></author><author><name sortKey="Warnke, Andreas" sort="Warnke, Andreas" uniqKey="Warnke A" first="Andreas" last="Warnke">Andreas Warnke</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</s1><s2>Würzburg</s2><s3>DEU</s3><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>33 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Grabe, Hans Jorgen" sort="Grabe, Hans Jorgen" uniqKey="Grabe H" first="Hans-Jörgen" last="Grabe">Hans-Jörgen Grabe</name></author><author><name sortKey="Mahler, Jessie" sort="Mahler, Jessie" uniqKey="Mahler J" first="Jessie" last="Mahler">Jessie Mahler</name></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name></author><author><name sortKey="Mors, Ole N" sort="Mors, Ole N" uniqKey="Mors O" first="Ole N." last="Mors">Ole N. Mors</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Centre for Psychiatric Research, Aarhus University Hospital</s1><s2>Risskov</s2><s3>DNK</s3><sZ>7 aut.</sZ><sZ>38 aut.</sZ></inist:fA14><country>Danemark</country><wicri:noRegion>Risskov</wicri:noRegion></affiliation></author><author><name sortKey="Sch Fer, Helmut" sort="Sch Fer, Helmut" uniqKey="Sch Fer H" first="Helmut" last="Sch Fer">Helmut Sch Fer</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Medical Biometry and Epidemiology, University of Marburg</s1><s2>Marburg</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>13 aut.</sZ><sZ>39 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Ramos Quiroga, Josep Antoni" sort="Ramos Quiroga, Josep Antoni" uniqKey="Ramos Quiroga J" first="Josep Antoni" last="Ramos-Quiroga">Josep Antoni Ramos-Quiroga</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Psychiatry, Hospital Universitari Vall d'Hebron</s1><s2>Barcelona, Catalonia</s2><s3>ESP</s3><sZ>18 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ><sZ>21 aut.</sZ><sZ>40 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Barcelona, Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Cormand, Bru" sort="Cormand, Bru" uniqKey="Cormand B" first="Bru" last="Cormand">Bru Cormand</name></author><author><name sortKey="Haavik, Jan" sort="Haavik, Jan" uniqKey="Haavik J" first="Jan" last="Haavik">Jan Haavik</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Biomedicine, University of Bergen</s1><s2>Bergen</s2><s3>NOR</s3><sZ>28 aut.</sZ><sZ>29 aut.</sZ><sZ>42 aut.</sZ></inist:fA14><country>Norvège</country><wicri:noRegion>Bergen</wicri:noRegion></affiliation></author><author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</s1><s2>Nijmegen</s2><s3>NLD</s3><sZ>26 aut.</sZ><sZ>27 aut.</sZ><sZ>43 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Lesch, Klaus Peter" sort="Lesch, Klaus Peter" uniqKey="Lesch K" first="Klaus-Peter" last="Lesch">Klaus-Peter Lesch</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</s1><s2>Wuerzburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ><sZ>44 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Wuerzburg</wicri:noRegion><wicri:noRegion>University of Wuerzburg</wicri:noRegion><wicri:noRegion>Wuerzburg</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neuropsychopharmacology : (New York, NY)</title><title level="j" type="abbreviated">Neuropsychopharmacology : (N.Y.N.Y)</title><idno type="ISSN">0893-133X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuropsychopharmacology : (New York, NY)</title><title level="j" type="abbreviated">Neuropsychopharmacology : (N.Y.N.Y)</title><idno type="ISSN">0893-133X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Attention disorder with hyperactivity</term><term>Bipolar disorder</term><term>Concomitant disease</term><term>Genome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term><term>Trouble déficitaire de l'attention avec hyperactivité</term><term>Association morbide</term><term>Génome</term><term>Trouble bipolaire</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several linkage analyses implicated the chromosome 9q22 region in attention deficit/hyperactivity disorder (ADHD), a neurodevelopmental disease with remarkable persistence into adulthood. This locus contains the brain-expressed GTP-binding RAS-like 2 gene (DIRAS2) thought to regulate neurogenesis. As DIRAS2 is a positional and functional ADHD candidate gene, we conducted an association study in 600 patients suffering from adult ADHD (aADHD) and 420 controls. Replication samples consisted of 1035 aADHD patients and I38I controls, as well as I66 families with a child affected from childhood ADHD. Given the high degree of co-morbidity with ADHD, we also investigated patients suffering from bipolar disorder (BD) (n = 336) or personality disorders (PDs) (n = 622). Twelve single-nucleotide polymorphisms (SNPs) covering the structural gene and the transcriptional control region of DIRAS2 were analyzed. Four SNPs and two haplotype blocks showed evidence of association with ADHD, with nominal p-values ranging from p = 0.006 to p = 0.05. In the adult replication samples, we obtained a consistent effect of rs I4I2005 and of a risk haplotype containing the promoter region (p = 0.026). Meta-analysis resulted in a significant common OR of I.I2 (p = 0.04) for rsI4I2005 and confrmed association with the promoter risk haplotype (OR= 1.45, p=0.0003). Subsequent analysis in nuclear families with childhood ADHD again showed an association of the promoter haplotype block (p = 0.02). rs I4I2005 also increased risk toward BD (p = 0.026) and cluster B PD (p = 0.03i). Additional SNPs showed association with personality scores (p = 0.008-0.048). Converging lines of evidence implicate genetic variance in the promoter region of DIRAS2 in the etiology of ADHD and co-morbid impulsive disorders.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Danemark</li><li>Espagne</li><li>Norvège</li><li>Pays-Bas</li><li>Suisse</li></country><region><li>Bavière</li><li>District de Basse-Franconie</li><li>District de Darmstadt</li><li>District de Giessen</li><li>Gueldre</li><li>Hesse (Land)</li><li>Rhénanie-Palatinat</li></region><settlement><li>Francfort-sur-le-Main</li><li>Marbourg</li><li>Nimègue</li><li>Trèves (Allemagne)</li><li>Wurtzbourg</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><noCountry><name sortKey="Asherson, Phil" sort="Asherson, Phil" uniqKey="Asherson P" first="Phil" last="Asherson">Phil Asherson</name><name sortKey="Cormand, Bru" sort="Cormand, Bru" uniqKey="Cormand B" first="Bru" last="Cormand">Bru Cormand</name><name sortKey="Fasmer, Ole B" sort="Fasmer, Ole B" uniqKey="Fasmer O" first="Ole B." last="Fasmer">Ole B. Fasmer</name><name sortKey="Grabe, Hans Jorgen" sort="Grabe, Hans Jorgen" uniqKey="Grabe H" first="Hans-Jörgen" last="Grabe">Hans-Jörgen Grabe</name><name sortKey="Mahler, Jessie" sort="Mahler, Jessie" uniqKey="Mahler J" first="Jessie" last="Mahler">Jessie Mahler</name><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name></noCountry><country name="Allemagne"><region name="Bavière"><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name></region><name sortKey="Freitag, Christine M" sort="Freitag, Christine M" uniqKey="Freitag C" first="Christine M." last="Freitag">Christine M. Freitag</name><name sortKey="Gessner, Alexandra" sort="Gessner, Alexandra" uniqKey="Gessner A" first="Alexandra" last="Gessner">Alexandra Gessner</name><name sortKey="Gross Lesch, Silke" sort="Gross Lesch, Silke" uniqKey="Gross Lesch S" first="Silke" last="Gross-Lesch">Silke Gross-Lesch</name><name sortKey="Jacob, Christian P" sort="Jacob, Christian P" uniqKey="Jacob C" first="Christian P." last="Jacob">Christian P. Jacob</name><name sortKey="Jacob, Christian P" sort="Jacob, Christian P" uniqKey="Jacob C" first="Christian P." last="Jacob">Christian P. Jacob</name><name sortKey="Kittel Schneider, Sarah" sort="Kittel Schneider, Sarah" uniqKey="Kittel Schneider S" first="Sarah" last="Kittel-Schneider">Sarah Kittel-Schneider</name><name sortKey="Kreiker, Susanne" sort="Kreiker, Susanne" uniqKey="Kreiker S" first="Susanne" last="Kreiker">Susanne Kreiker</name><name sortKey="Kreiker, Susanne" sort="Kreiker, Susanne" uniqKey="Kreiker S" first="Susanne" last="Kreiker">Susanne Kreiker</name><name sortKey="Lesch, Klaus Peter" sort="Lesch, Klaus Peter" uniqKey="Lesch K" first="Klaus-Peter" last="Lesch">Klaus-Peter Lesch</name><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><name sortKey="Neuner, Maria" sort="Neuner, Maria" uniqKey="Neuner M" first="Maria" last="Neuner">Maria Neuner</name><name sortKey="Renner, Tobias J" sort="Renner, Tobias J" uniqKey="Renner T" first="Tobias J." last="Renner">Tobias J. Renner</name><name sortKey="Romanos, Marcel" sort="Romanos, Marcel" uniqKey="Romanos M" first="Marcel" last="Romanos">Marcel Romanos</name><name sortKey="Sch Fer, Helmut" sort="Sch Fer, Helmut" uniqKey="Sch Fer H" first="Helmut" last="Sch Fer">Helmut Sch Fer</name><name sortKey="Trang Nguyen, T" sort="Trang Nguyen, T" uniqKey="Trang Nguyen T" first="T." last="Trang Nguyen">T. Trang Nguyen</name><name sortKey="Warnke, Andreas" sort="Warnke, Andreas" uniqKey="Warnke A" first="Andreas" last="Warnke">Andreas Warnke</name><name sortKey="Weber, Heike" sort="Weber, Heike" uniqKey="Weber H" first="Heike" last="Weber">Heike Weber</name><name sortKey="Weissflog, Lena" sort="Weissflog, Lena" uniqKey="Weissflog L" first="Lena" last="Weissflog">Lena Weissflog</name><name sortKey="Zamzow, Karin" sort="Zamzow, Karin" uniqKey="Zamzow K" first="Karin" last="Zamzow">Karin Zamzow</name></country><country name="Danemark"><noRegion><name sortKey="Buttenschon, Henriette N" sort="Buttenschon, Henriette N" uniqKey="Buttenschon H" first="Henriette N." last="Buttenschon">Henriette N. Buttenschon</name></noRegion><name sortKey="Mors, Ole N" sort="Mors, Ole N" uniqKey="Mors O" first="Ole N." last="Mors">Ole N. Mors</name></country><country name="Suisse"><noRegion><name sortKey="Walitza, Susanne" sort="Walitza, Susanne" uniqKey="Walitza S" first="Susanne" last="Walitza">Susanne Walitza</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Bosch, Rosa" sort="Bosch, Rosa" uniqKey="Bosch R" first="Rosa" last="Bosch">Rosa Bosch</name></noRegion><name sortKey="Bayes, M Nica" sort="Bayes, M Nica" uniqKey="Bayes M" first="M Nica" last="Bayes">M Nica Bayes</name><name sortKey="Casas, Miquel" sort="Casas, Miquel" uniqKey="Casas M" first="Miquel" last="Casas">Miquel Casas</name><name sortKey="Gomez, Nuria" sort="Gomez, Nuria" uniqKey="Gomez N" first="Nuria" last="Gomez">Nuria Gomez</name><name sortKey="Ramos Quiroga, Josep Antoni" sort="Ramos Quiroga, Josep Antoni" uniqKey="Ramos Quiroga J" first="Josep Antoni" last="Ramos-Quiroga">Josep Antoni Ramos-Quiroga</name><name sortKey="Ribases, Marta" sort="Ribases, Marta" uniqKey="Ribases M" first="Marta" last="Ribases">Marta Ribases</name></country><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Buitelaar, Jan K" sort="Buitelaar, Jan K" uniqKey="Buitelaar J" first="Jan K." last="Buitelaar">Jan K. Buitelaar</name></region><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><name sortKey="Hoogman, Martine" sort="Hoogman, Martine" uniqKey="Hoogman M" first="Martine" last="Hoogman">Martine Hoogman</name><name sortKey="Kan, Cees C" sort="Kan, Cees C" uniqKey="Kan C" first="Cees C." last="Kan">Cees C. Kan</name><name sortKey="Kiemeney, Lambertus Alm" sort="Kiemeney, Lambertus Alm" uniqKey="Kiemeney L" first="Lambertus Alm" last="Kiemeney">Lambertus Alm Kiemeney</name><name sortKey="Kooij, J J Sandra" sort="Kooij, J J Sandra" uniqKey="Kooij J" first="J. J. Sandra" last="Kooij">J. J. Sandra Kooij</name></country><country name="Norvège"><noRegion><name sortKey="Johansson, Stefan" sort="Johansson, Stefan" uniqKey="Johansson S" first="Stefan" last="Johansson">Stefan Johansson</name></noRegion><name sortKey="Haavik, Jan" sort="Haavik, Jan" uniqKey="Haavik J" first="Jan" last="Haavik">Jan Haavik</name><name sortKey="Jacobsen, Kaya K" sort="Jacobsen, Kaya K" uniqKey="Jacobsen K" first="Kaya K." last="Jacobsen">Kaya K. Jacobsen</name><name sortKey="Jacobsen, Kaya K" sort="Jacobsen, Kaya K" uniqKey="Jacobsen K" first="Kaya K." last="Jacobsen">Kaya K. Jacobsen</name><name sortKey="Johansson, Stefan" sort="Johansson, Stefan" uniqKey="Johansson S" first="Stefan" last="Johansson">Stefan Johansson</name><name sortKey="Knappskog, Per M" sort="Knappskog, Per M" uniqKey="Knappskog P" first="Per M." last="Knappskog">Per M. Knappskog</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B02 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B02 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Rhénanie
|area= UnivTrevesV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:11-0458339
|texte= DIRAS2 is Associated with Adult ADHD, Related Traits, and Co-Morbid Disorders
}}
| This area was generated with Dilib version V0.6.31. |  |